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The glutamate is joined to cysteine through its side-chain () carboxyl rather than the -carboxyl group used in an ordinary peptide backbone bond, so the molecule is described as peptide-like rather than as a conventional linear peptide

This was based on the evidence collected from seven clinical trials conducted in 33 countries with 4,087 patients with type 2 diabetes (US FDA 2017

By activating GLP-1 receptors, these medications help to slow gastric emptying, increase insulin secretion, and promote a feeling of fullness, all of which contribute to reduced calorie intake and weight loss